Fig.8

Distribution of HTRF activities for 2029 compounds. 2029 compounds were tested in biochemical WDR5-MYC PPI HTRF assay at 40 μM with duplicates, each indicated in red or blue. The control DMSO activity was set up as 100% for normalization. Compounds showing greater than 40% inhibition were considered as the primary hits. The published probe WM-662 was highlighted by the circle as the positive control inhibitor. X-axis: compound. Y-axis: HTRF activity. Dash line: 40% inhibition