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Table 4 Conserved ACE residues important for inhibitor interactions

From: Interpretable correlation descriptors for quantitative structure-activity relationships

Functional interaction

C-domain residue

N-domain residue

Zinc-binding

383His

361His

Zinc-binding

387His

365His

Zinc-binding

411Glu

389Glu

Inhibitor carbonyl hydrogen bonding

513His

491His

Inhibitor carbonyl hydrogen bonding

353His

331His

Inhibitor carboxy terminal carboxylic ionic bonding

511Lys

489Lys

Inhibitor carboxy terminal carboxylic hydrogen bonding

281Gln

259Gln

Inhibitor carboxy terminal carboxylic hydrogen bonding

520Tyr

498Tyr

  1. (Table formulated using information from [29, 30, 32])