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Table 5 Top-20 target rankings by compound count and molecular frameworks.

From: Analysis of in vitrobioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds

Cmpd ranking Target symbol MF2 ranking Target symbol GS ranking Target symbol
1 F10 1 F10 1 F10
2 CNR1 7 HRH3 7 HRH3
3 KDR 2 CNR1 3 KDR
4 MAPK14 6 F2 6 F2
5 DRD3 3 KDR 2 CNR1
6 F2 5 DRD3 24 OPRM1
7 HRH3 28 CTSS 20 MC4R
8 TACR1 8 TACR1 5 DRD3
9 MMP13 10 CNR2 8 TACR1
10 CNR2 12 ADORA2A 29 CHRM3
11 MMP1 4 MAPK14 28 CTSS
12 ADORA2A 29 CHRM3 26 REN
13 EGFR 9 MMP13 10 CNR2
14 SLC6A4 26 REN 4 MAPK14
15 MMP9 24 OPRM1 12 ADORA2A
16 HTR6 23 CCR3 31 DRD2
17 MMP2 20 MC4R 38 MCHR1
18 HTR2C 17 MMP2 37 SRC
19 CRHR1 11 MMP1 16 HTR6
20 MC4R 25 DPP4 49 ELANE
  1. Columns 1 and 2 are the compound count ranking, columns 3 and 4 show the molecular framework 2 (MF2) ranking and colums 5 and 6 show the graph scaffold (GS) ranking.