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Table 5 Top-20 target rankings by compound count and molecular frameworks.

From: Analysis of in vitrobioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds

Cmpd ranking

Target symbol

MF2 ranking

Target symbol

GS ranking

Target symbol

1

F10

1

F10

1

F10

2

CNR1

7

HRH3

7

HRH3

3

KDR

2

CNR1

3

KDR

4

MAPK14

6

F2

6

F2

5

DRD3

3

KDR

2

CNR1

6

F2

5

DRD3

24

OPRM1

7

HRH3

28

CTSS

20

MC4R

8

TACR1

8

TACR1

5

DRD3

9

MMP13

10

CNR2

8

TACR1

10

CNR2

12

ADORA2A

29

CHRM3

11

MMP1

4

MAPK14

28

CTSS

12

ADORA2A

29

CHRM3

26

REN

13

EGFR

9

MMP13

10

CNR2

14

SLC6A4

26

REN

4

MAPK14

15

MMP9

24

OPRM1

12

ADORA2A

16

HTR6

23

CCR3

31

DRD2

17

MMP2

20

MC4R

38

MCHR1

18

HTR2C

17

MMP2

37

SRC

19

CRHR1

11

MMP1

16

HTR6

20

MC4R

25

DPP4

49

ELANE

  1. Columns 1 and 2 are the compound count ranking, columns 3 and 4 show the molecular framework 2 (MF2) ranking and colums 5 and 6 show the graph scaffold (GS) ranking.