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Table 1 Aryl-amine mutagenicity data sets considered in this study.

From: An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential

Set Description Number of molecules Number of Ames+ Number of Ames-
Aryl-amines Only
A Novartis 2009 327 72 255
B Kazius 2005[21]/Hansen 2009[38] 461 327 134
All compound classes
C Novartis 2754 360 2394
D Hansen[38] 6512 3503 3009
E Marketed Pharmaceuticals[44] 378 44 334
F Kazius[21]a 4195 2343 1852
  Combined C, D, E, and Fa 9423a 3591b 5832b
  1. aMW < 700
  2. bAmes+ if either C, D, E, or F are Ames+