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Table 1 Aryl-amine mutagenicity data sets considered in this study.

From: An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential

Set

Description

Number of molecules

Number of Ames+

Number of Ames-

Aryl-amines Only

A

Novartis 2009

327

72

255

B

Kazius 2005[21]/Hansen 2009[38]

461

327

134

All compound classes

C

Novartis

2754

360

2394

D

Hansen[38]

6512

3503

3009

E

Marketed Pharmaceuticals[44]

378

44

334

F

Kazius[21]a

4195

2343

1852

 

Combined C, D, E, and Fa

9423a

3591b

5832b

  1. aMW < 700
  2. bAmes+ if either C, D, E, or F are Ames+