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Table 2 Results for Multiconf-DOCK showing the relationship between the number of rotatable bonds, the number of conformers generated and the minimum RMSD to the crystal structure.

From: Confab - Systematic generation of diverse low-energy conformers

Rotatable bonds Diverse Conformers (median) Minimum RMSD to crystal (median)
  1.0 Å 1.5 Å 2.0 Å 1.0 Å 1.5 Å 2.0 Å
1 1 1 1 0.34 0.40 0.40
2 3 1 1 0.50 0.67 0.71
3 2 1 1 0.68 0.78 0.81
4 9 3 1 0.76 0.97 1.05
5 14 4 2 0.85 1.03 1.28
6 43 15 5 1.08 1.23 1.37
7 21 8 3 1.04 1.24 1.40