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Table 2 Top 20 PS α scores for targets

From: Predicting the mechanism of phospholipidosis

Rank Name PS α
1 5-hydroxytryptamine receptor 2B (r) 444
2 5-hydroxytryptamine receptor 2C (r) 443
3 D(2) dopamine receptor (r) 436
4 5-hydroxytryptamine receptor 1A (r) 409
5 Potassium voltage-gated channel subfamily H member 2 (h) 406
6 Sodium-dependent serotonin transporter (r) 394
7 = D(3) dopamine receptor (r) 385
7 = D(3) dopamine receptor (h) 385
9 Muscarinic acetylcholine receptor M5 (r) 379
10 Alpha-1D adrenergic receptor (r) 376
11 Alpha-1A adrenergic receptor (r) 371
12 Alpha-1B adrenergic receptor (r) 369
13 5-hydroxytryptamine receptor 2A (r) 367
14 = Sodium-dependent serotonin transporter (h) 357
14 = 5-hydroxytryptamine receptor 1B (r) 357
16 = Transporter (r) 350
16 = Muscarinic acetylcholine receptor M1 (r) 350
18 Sodium-dependent dopamine transporter (r) 349
19 Sigma 1-type opioid receptor (h) 348
20 Sodium channel protein type 2 subunit alpha (h) 347
  1. List of the top 20 targets ranked by their PS α scores across all 182 compounds over the ten models derived from the ten different partitions of the ChEMBL dataset. A higher PS α score suggests that more phospholipidosis positive than negative compounds are associated with the target. A large number of the highly placed targets in our PS α rankings are the intended drug targets of CADs. Each of the top 20 targets comes from either human (h) or rat (r). Tied ranks are denoted by =.