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Table 2 Top 20 PS α scores for targets

From: Predicting the mechanism of phospholipidosis

Rank

Name

PS α

1

5-hydroxytryptamine receptor 2B (r)

444

2

5-hydroxytryptamine receptor 2C (r)

443

3

D(2) dopamine receptor (r)

436

4

5-hydroxytryptamine receptor 1A (r)

409

5

Potassium voltage-gated channel subfamily H member 2 (h)

406

6

Sodium-dependent serotonin transporter (r)

394

7 =

D(3) dopamine receptor (r)

385

7 =

D(3) dopamine receptor (h)

385

9

Muscarinic acetylcholine receptor M5 (r)

379

10

Alpha-1D adrenergic receptor (r)

376

11

Alpha-1A adrenergic receptor (r)

371

12

Alpha-1B adrenergic receptor (r)

369

13

5-hydroxytryptamine receptor 2A (r)

367

14 =

Sodium-dependent serotonin transporter (h)

357

14 =

5-hydroxytryptamine receptor 1B (r)

357

16 =

Transporter (r)

350

16 =

Muscarinic acetylcholine receptor M1 (r)

350

18

Sodium-dependent dopamine transporter (r)

349

19

Sigma 1-type opioid receptor (h)

348

20

Sodium channel protein type 2 subunit alpha (h)

347

  1. List of the top 20 targets ranked by their PS α scores across all 182 compounds over the ten models derived from the ten different partitions of the ChEMBL dataset. A higher PS α score suggests that more phospholipidosis positive than negative compounds are associated with the target. A large number of the highly placed targets in our PS α rankings are the intended drug targets of CADs. Each of the top 20 targets comes from either human (h) or rat (r). Tied ranks are denoted by =.