Table 2 First line drugs active against Mtb evaluated in TB Mobile app and the top 3 molecules
From: TB Mobile: a mobile app for anti-tuberculosis molecules with known targets
Molecule | Name | 1st | 2nd | 3rd |
|---|---|---|---|---|
| Amikacin | Amikacin (FusA1, FusA2, Tuf, EngA, Era) | Kanamycin (FusA1, FusA2, Tuf, RplC, InfB) | Streptomycin (FusA1, FusA2, Tuf, RplC) |
| Aminosalicylic acid | Aminosalicylic acid (FolP1, FolP2) | (Rv1885c) | Nicotinamide (SahH) |
| Capreomycin 1A | Capreomycin 1A (TlyA) | Capreomycin 1B (RplJ, TlyA) | Capreomycin (RplJ) |
| Capreomycin 1B | Capreomycin 1B (RplJ, TlyA) | Capreomycin (TlyA) | Capreomycin (RplJ) |
| D-Cycloserine | D-cycloserine (Alr) | Ethambutol (EmbA, EmbB, EmbC) | (DapA) |
| Ethambutol | Ethambutol (EmbA, EmbB, EmbC) | (DapA) | D-cycloserine (Alr) |
| Ethionamide | Ethionamide (InhA) | Prothionamide (SahH) | Nicotinamide (SahH) |
| Gatifloxacin | Gatifloxacin (GyrA) | Moxifloxacin (Murd, PurU) | Ciprofloxacin (GyrA) |
| Isoniazid | Isoniazid (InhA, KasA, DfrA) | Nicotinamide (SahH) | Ethionamide (InhA) |
| Kanamycin | Kanamycin (FusA1, FusA2, Tuf, RplC, InfB) | Amikacin (FusA1, FusA2, Tuf, EngA, Era) | Streptomycin (FusA1, FusA2, Tuf, RplC) |
| Moxifloxacin | Moxifloxacin (Murd, PurU) | (GyrA) | Gatifloxacin (GyrA) |
| Pyrazinamide | Pyrazinamide (NedR) | Pyrazinoic acid (deaD, Mfd, RecG, DinG, NedR) | Nicotinamide (SahH) |
| Rifampin | Rifampin (RpoB) | Rifapentine (RpoB) | Rifabutin (RpoB) |
| Streptomycin | Streptomycin (FusA1, FusA2, Tuf, RplC) | Amikacin (FusA1, FusA2, Tuf, EngA, Era) | Kanamycin (FusA1, FusA2, Tuf, RplC, InfB) |
