Molecular XOR gate generated using P-ERM computational protocol. Molecular XOR gate generated using P-ERM computational protocol (selected from successful candidates in T1). The inactive conformation of the molecule (top left) changes in the presence of effector molecule E1, to the active ribozyme conformation (bottom left). The presence of effector molecule E2 triggers a different conformation shift, that also activate the ribozymes (middle bottom). The presence of both effectors stretches out both binding regions and disrupts the formation of an active hammerhead motif (right).