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Table 1 Top drug repositioning predictions

From: Drug repositioning: a machine-learning approach through data integration

Drug name

Original ATC therapeutic class

Predicted ATC therapeutic class

Carbamazepine

Antiepileptics (N03)

Cardiac therapy (C01)

Chlorphenamine

Antihistamines for systemic use (R06)

Psychoanaleptics (N06)

Dobutamine

Cardiac therapy (C01)

Beta blocking agents (C07)

Gefitinib

Antineoplastic agents (L01)

Antibacterials for systemic use (J01)

Hydroxyzine

Psycholeptics (N05)

Antihistamines for systemic use (R06)

Ivermectin

Anthelmintics (P02)

Antibacterials for systemic use (J01)

Levobunolol

Ophthalmologicals (S01)

Beta blocking agents (C07)

Niclosamide

Anthelmintics (P02)

Antineoplastic agents (L01)

Oxamniquine

Anthelmintics (P02)

Antineoplastic agents (L01)

Spironolactone

Diuretics (C03)

Sex hormones and modulators of the genital system (G03)

Sulfacetamide

Ophthalmologicals (S01)

Antibacterials for systemic use (J01)

Thiethylperazine

Antihistamines for systemic use (R06)

Psycholeptics (N05)

  1. The top 12 repositioned drugs (classification score =1) are shown in rows. The drug name, the original and the predicted therapeutic class are reported. The level 2 ATC codes are also reported in brackets.