Skip to main content

Table 4 Cannabinoid results

From: Predicting the protein targets for athletic performance-enhancing substances

Compound

Target

PR-Score

E-Value

S8-Cannabinoids

Cannabidivarin (−)

Cannabinoid CB1 receptor (218)

0.037

Prediction

Cannabinoid CB2 receptor (253)

0.037

Prediction

Cannabigerol (497318)

HL-60 (383)

0.047

Prediction

HU-210 (70625)

Cannabinoid CB1 receptor (3571)

0.035

Ki = 0.82 nM a

Cannabinoid CB2 receptor (5373)

0.029

Prediction

JWH-018 (561013)

Cannabinoid CB1 receptor (218)

0.002

pKi = 8.7

Cannabinoid CB1 receptor (3571)

0.015

pKi = 8.045

Cannabinoid CB2 receptor (253)

0.009

pKi = 8.2

Isoprenylcysteine carboxyl methyltransferase (4699)

0.031

Prediction

MDA-MB-231 (400)

0.030

Prediction

JWH-073 (−)

Cannabinoid CB1 receptor (218)

0.002

Prediction

Cannabinoid CB1 receptor (3571)

0.025

Prediction

Tetrahydrocannabinol (465)

Cannabinoid CB1 receptor (218)

0.037

Ki = 2.9 nM

Cannabinoid CB1 receptor (3571)

0.037

Ki = 37 nM

Cannabinoid CB2 receptor (2470)

0.034

Ki = 20 nM

Cannabinoid CB2 receptor (253)

0.033

Ki = 3.3 nM

 

Cannabinoid CB2 receptor (5373)

0.049

Ki = 9.2 nM

  1. Experimental validation of the predictions for the most significant PR-Scores (≤0.05) for the Cannabinoid S8 WADA class. Where no experimental activity exists in ChEMBL, the compound-family association retains the status of ‘Prediction’.
  2. aThe experimental value is for the corresponding receptor in Homo sapiens while the PR-Score is for the receptor in Rattus norvegicus. The PR-Score for the Homo sapiens receptor was just a little above the 0.05 threshold at 0.067.