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Table 4 Cannabinoid results

From: Predicting the protein targets for athletic performance-enhancing substances

Compound Target PR-Score E-Value
S8-Cannabinoids
Cannabidivarin (−) Cannabinoid CB1 receptor (218) 0.037 Prediction
Cannabinoid CB2 receptor (253) 0.037 Prediction
Cannabigerol (497318) HL-60 (383) 0.047 Prediction
HU-210 (70625) Cannabinoid CB1 receptor (3571) 0.035 Ki = 0.82 nM a
Cannabinoid CB2 receptor (5373) 0.029 Prediction
JWH-018 (561013) Cannabinoid CB1 receptor (218) 0.002 pKi = 8.7
Cannabinoid CB1 receptor (3571) 0.015 pKi = 8.045
Cannabinoid CB2 receptor (253) 0.009 pKi = 8.2
Isoprenylcysteine carboxyl methyltransferase (4699) 0.031 Prediction
MDA-MB-231 (400) 0.030 Prediction
JWH-073 (−) Cannabinoid CB1 receptor (218) 0.002 Prediction
Cannabinoid CB1 receptor (3571) 0.025 Prediction
Tetrahydrocannabinol (465) Cannabinoid CB1 receptor (218) 0.037 Ki = 2.9 nM
Cannabinoid CB1 receptor (3571) 0.037 Ki = 37 nM
Cannabinoid CB2 receptor (2470) 0.034 Ki = 20 nM
Cannabinoid CB2 receptor (253) 0.033 Ki = 3.3 nM
  Cannabinoid CB2 receptor (5373) 0.049 Ki = 9.2 nM
  1. Experimental validation of the predictions for the most significant PR-Scores (≤0.05) for the Cannabinoid S8 WADA class. Where no experimental activity exists in ChEMBL, the compound-family association retains the status of ‘Prediction’.
  2. aThe experimental value is for the corresponding receptor in Homo sapiens while the PR-Score is for the receptor in Rattus norvegicus. The PR-Score for the Homo sapiens receptor was just a little above the 0.05 threshold at 0.067.