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Figure 6 | Journal of Cheminformatics

Figure 6

From: Visualizing chemical structure-subcellular localization relationships using fluorescent small molecules as probes of cellular transport

Figure 6

Visualizing the relationship between the staining pattern of a reference probe (located at the upper left corner of the array; probe structure indicated by arrow) and the staining patterns of related compounds. Different aldehyde building blocks are plotted in rows (left) and pyridinium or quinolinium building blocks are plotted in columns (top), in order of their calculated similarity to the building block of the reference compound on the top left. Numbers correspond to the Tanimoto coefficients between the different building blocks and the building blocks of the reference compound at the upper-left most corner of the array. To assemble figures, individual cells representing the staining patterns observed in each image were manually cropped from the images, and labeled based on their apparent organelle (o), membrane (m) or nuclear (n) staining patterns. Cells from images lacking significant signal or ambiguous in localization patterns were not labeled.

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