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Figure 2 | Journal of Cheminformatics

Figure 2

From: Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases

Figure 2

Distribution of the number of kinases as a function of compounds inhibiting the respective number of kinases. Compounds that lowered bioactivity of the kinase in question by 50% or more were considered active. Overall, kinases in the dataset were inhibited by 1 to 70 compounds in most cases. This indicates that our kinome dataset contains a wide range of kinases, including those that are promiscuous to multiple compounds as well as selective kinases.

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