Figure 1

General framework for building drug-disease associations. This figure shows the general framework for our proposed paradigm. Steps 1 and 2 were used to extract the initial set of genes. Steps 3.1 and 3.2 extracted drug-gene and disease-gene co-occurrences, respectively. Steps 3.3 and 3.4 extracted drug microarray and disease microarray data respectively. In step 4 we found the ranks of genes related to a specific drug or disease. In step 5 we built the drug-specific and disease-specific gene-gene network. In step 6 we ran prioritization procedures as to launch drug-gene and disease-gene interaction networks into a lasso regression. In step 7 we used lasso regression model to build drug-disease associations.