Figure 2

Generating a disease-specific and drug-specific gene-gene network. This figure shows the process of generating the drug-specific and disease-specific gene-gene network. The process starts by finding all possible interactions between the initial set of genes in steps 2.1 and 2.2 both from a text-mining source and a functional PPI source, respectively. The initial list of genes for each disease and each drug are then used to query the extracted network in a data source specific manner. Finally the interactions between these genes and their direct neighbors would be considered as a disease-specific or drug-specific gene-gene network.