Table 2 Antimicrobial and anticancer activities of a representative set of small-molecules b
Proteina | Identity (NSC) | DH5α (MIC) | MDREC (MIC) | MRSA (MIC) | VREF (MIC) | HCT-116 (IC-50) |
|---|---|---|---|---|---|---|
DHFR | 309401 | 7.813 | 125 | 31.25 | 31.25 | 0.130 |
740* | ND | ND | ND | 500 | 0.048 | |
339578* | 62.5 | 250 | 31.25 | 31.25 | 6.11 | |
382035* | ND | ND | 31.25 | 31.25 | 0.182 | |
754230* | ND | ND | ND | ND | <<0.031 | |
1000001 | 111552 | NA | NA | NA | NA | 2.2 |
246131@ | NA | NA | NA | NA | 0.024 | |
30205 | NA | NA | NA | NA | 0.146 | |
88882 | NA | NA | N A | NA | 4.44 | |
| Â | 106863 | NA | NA | NA | NA | 14.5 |
1000006 | 92794 | NA | NA | NA | NA | 9.78 |
TrpRS | 750690Â¥ | NA | NA | NA | NA | 1.11 |
88882 | NA | NA | NA | NA | 4.44 | |
37168 | NA | NA | NA | NA | 1.34 |