|
Proteina
|
Identity (NSC)
|
DH5α (MIC)
|
MDREC (MIC)
|
MRSA (MIC)
|
VREF (MIC)
|
HCT-116 (IC-50)
|
|---|
|
DHFR
|
309401
|
7.813
|
125
|
31.25
|
31.25
|
0.130
|
|
740*
|
ND
|
ND
|
ND
|
500
|
0.048
|
|
339578*
|
62.5
|
250
|
31.25
|
31.25
|
6.11
|
|
382035*
|
ND
|
ND
|
31.25
|
31.25
|
0.182
|
|
754230*
|
ND
|
ND
|
ND
|
ND
|
<<0.031
|
|
1000001
|
111552
|
NA
|
NA
|
NA
|
NA
|
2.2
|
|
246131@
|
NA
|
NA
|
NA
|
NA
|
0.024
|
|
30205
|
NA
|
NA
|
NA
|
NA
|
0.146
|
|
88882
|
NA
|
NA
|
N A
|
NA
|
4.44
|
| |
106863
|
NA
|
NA
|
NA
|
NA
|
14.5
|
|
1000006
|
92794
|
NA
|
NA
|
NA
|
NA
|
9.78
|
|
TrpRS
|
750690¥
|
NA
|
NA
|
NA
|
NA
|
1.11
|
|
88882
|
NA
|
NA
|
NA
|
NA
|
4.44
|
|
37168
|
NA
|
NA
|
NA
|
NA
|
1.34
|
- *Reported inhibitors of DHFR independently picked up by our predictions and validated experimentally. @Small molecule with known anti-cancer properties (valrubicin). ¥Small molecules with known anticancer properties (Sunitinib), MIC: Minimum inhibitory concentration required for 90% clearance, μg/mL units. ND: No significant inhibition. NA: not applicable. DH5α: E. coli strain DH5α, MRSA: Methicillin-resistant S. aureus, MDREC: Multi-drug resistant E. coli, VREF: Vancomycin-resistant E. faecium, HCT-116: Colon carcinoma cell line. IC-50: inhibitory concentration for 50% growth inhibition, μg/mL units. aFor additional details, see legend from Table 1. bThe values reported in this table are experimental in-vitro values.
