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Table 3 Performance of methods on the 40 protein DUD set using experimental structures

From: Experimental validation of FINDSITEcomb virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders

Method Average EF0.01 Average EF0.05 Average EF0.1 Average AUAC
FINDSITEcomb 13.4 6.56 4.37 0.774
AUTODOCK Vina 4.80 3.01 2.40 0.586
  (5.3×10-4)a (9.4×10-4) (7.7×10-4) (3.0×10-7)
DOCK 6 3.72 1.79 1.24 0.426
  (1.5×10-4) (1.8×10-5) (9.9×10-7) (1.3×10-12)
  1. aNumbers in parentheses are two-sided p-values of Student-t test between FINDSITEcomb and docking methods.