Figure 5

Similarity comparisons of cannabinoids. Test compounds are divided into broad categories (JWH series, AM/UR/RCS/XLR series, other synthetic cannabinoids not possessing the chemical backbone of THC, cannabinoids sharing chemical backbone of THC, endogenous eicosanoid cannabinoids, and non-cannabinoids). (A) 2D similarity of the N-pentanoic acid metabolite of JWH-018 to 168 other compounds. (B) 2D similarity of the N-butanoic acid metabolite of JWH-073 to 168 other compounds. (C) 2D similarity of the N-4-hydroxy metabolite of JWH-250 to 168 other compounds. (D) 2D similarity of 9-carboxy-THC to 168 other compounds.