Figure 6

Descriptor importance for the dengue virus NS3 proteases dataset. Descriptor importance is calculated in the frame of Bayesian Automatic Relevance Determination (ARD) as the inverse of the value of the length scale of each descriptor. The descriptors of the first and second residues of the tetra-peptides (positions P1’ and P2’) are the most relevant for the model. This is in agreement with the higher influence of these two substrate positions for the cleavage rates of the proteases.