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Table 2 Names and hepatotoxicity classes a of the drugs that matched the structural alerts defined in Table 1

From: Data-driven identification of structural alerts for mitigating the risk of drug-induced human liver injuries

Drug name Class Drug name Class Drug name Class Drug name Class
Alert 1 Ketoprofen 0 Alert 7 Efavirenz 1
Triamcinolone 1 Naproxen 0 Ebrotidine 1 Nilutamide 0
Prednisone 1 Tolmetin 0 Niperotidine 1 Fluoxetine 0
Prednisolone 1 Alert 4 Penicillamine 1 Fluvoxamine 0
Methylprednisolone 1 Zafirlukast 1 Nelfinavir 1 Sitagliptin 0
Hydrocortisone 1 Piroxicam 1 Imipenem 1 Flucytosine 0
Dexamethasone 1 Tipranavir 1 Meropenem 1 Fluorouracil 0
Cortisone 1 Delavirdine 1 Disulfiram 1 Nilotinib 0
Betamethasone 1 Glyburide 1 Azathioprine 1 Fluphenazine 0
Testosterone 1 Glipizide 1 Spironolactone 0 Celecoxib 0
Stanozolol 1 Glimepiride 1 Clindamycin 0 Clindamycin 0
Oxymetholone 1 Gliclazide 1 Ceftriaxone 0 Riluzole 0
Oxandrolone 1 Fosamprenavir 1 Ertapenem 0 Maraviroc 0
Norethandrolone 1 Amprenavir 1 Ranitidine 0 Chlorambucil 0
Nandrolone 1 Tolbutamide 1 Nizatidine 0 Cyclophosphamide 0
Methyltestosterone 1 Tolazamide 1 Famotidine 0 Lomustine 0
Methenolone 1 Chlorpropamide 1 Cimetidine 0 Melphalan 0
Methandienone 1 Acetohexamide 1 Thioridazine 0 Bendroflumethiazide 0
Fluoxymesterone 1 Ebrotidine 1 Pergolide 0 Methyclothiazide 0
Danazol 1 Sudoxicam 1 Montelukast 0 Polythiazide 0
Exemestane 0 Sulfasalazine 1 Polythiazide 0 Silodosin 0
Spironolactone 0 Sulfadiazine 1 Albendazole 0 Desflurane 0
Dutasteride −1 Sulfamethoxazole 0 Captopril 0 Sevoflurane 0
Finasteride −1 Meloxicam 0 Cefazolin −1 Bicalutamide 0
Eplerenone −1 Sildenafil 0 Alert 8 Capecitabine −1
Alert 2 Darunavir 0 Bromfenac 1 Emtricitabine −1
Diclofenac 1 Sulfadoxine 0 Tienilic acid 1 Mechlorethamine −1
Pirprofen 1 Rosuvastatin 0 Zomepirac 1 Dutasteride −1
Lumiracoxib 1 Sotalol 0 Clometacin 1 Colestipol −1
Fenclozic acid 1 Chlorothiazide 0 Benziodarone 1 Quazepam −1
Fenclofenac 1 Polythiazide 0 Amiodarone 1 Chloral hydrate −1
Clometacin 1 Methyclothiazide 0 Benzbromarone 1 Alert 10
Zomepirac 1 Hydrochlorothiazide 0 Tolcapone 1 Nevirapine 1
Ibufenac 1 Bendroflumethiazide 0 Fenofibrate 1 Trovafloxacin 1
Bromfenac 1 Sumatriptan 0 Mebendazole 0 Abacavir sulfate 1
Benoxaprofen 1 Naratriptan 0 Indomethacin 0 Ciprofloxacin 1
Alclofenac 1 Almotriptan 0 Ketoprofen 0 Saxagliptin 0
Fexofenadine 0 Bosentan 0 Tolmetin 0 Tranylcypromine 0
Ticarcillin 0 Probenecid −1 Ketorolac −1 Gemifloxacin 0
Ibuprofen 0 Torsemide −1 Alert 9 Moxifloxacin 0
Indomethacin 0 Vardenafil −1 Leflunomide 1 Alert 11
Ketoprofen 0 Alert 5 Isoflurane 1 Amodiaquine 1
Naproxen 0 Sulfadiazine 1 Enflurane 1 Ketoconazole 1
Tolmetin 0 Bromfenac 1 Triamcinolone 1 Minocycline 1
Alert 3 Nomifensine 1 Dexamethasone 1 Sulfasalazine 1
Diclofenac 1 Amprenavir 1 Betamethasone 1 Posaconazole 1
Pirprofen 1 Fosamprenavir 1 Tipranavir 1 Acetaminophen 0
Lumiracoxib 1 Procainamide 1 Pantoprazole 1 Itraconazole 0
Fenclozic acid 1 Lenalidomide 1 Lansoprazole 1 Acebutolol 0
Fenclofenac 1 Sulfadoxine 0 Trifluoperazine 1 Lapatinib 0
Clometacin 1 Darunavir 0 Gemcitabine 1 Tigecycline −1
Zomepirac 1 Dapsone 0 Floxuridine 1 Alert 12
Ibufenac 1 Sulfamethoxazole 0 Mefloquine 1 Chlorpromazine 1
Bromfenac 1 Alert 6 Flecainide 1 Pipamazine 1
Benoxaprofen 1 Sulindac 1 Flutamide 1 Perphenazine 1
Alclofenac 1 Lansoprazole 1 Halothane 1 Prochlorperazine 1
Fexofenadine 0 Omeprazole 1 Fluoxymesterone 1 Trifluoperazine 1
Ticarcillin 0 Pantoprazole 1 Ifosfamide 1 Fluphenazine 0
Ibuprofen 0 Rabeprazole 1 Carmustine 1 Thioridazine 0
Indomethacin 0 Modafinil −1 Tolrestat 1 Promethazine −1
  1. aExpanded LiverTox dataset compound classes: 1, hepatotoxic; −1, nonhepatotoxic ; 0, possible hepatotoxic.