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Table 2 Multiple targets of selected drugs and natural products in the MTLD

From: Creation of a free, Internet-accessible database: the Multiple Target Ligand Database

Ligand (ligand-ID) Target number Targets (PDB-ID)
Sutent (B49) 4 Mast/stem cell growth factor (3G0E)
Phosphorylase b kinase gamma (2Y7J)
Cyclin-dependent kinase 2 (3TI1)
Tyrosine-protein kinase ITK/TSK (3MIY)
Imatinib (STI) 5 Homo sapiens v-kit Hardy–Zuckerman (1 T46)
Ribosyldihydronicotinamide dehydrogenase (3FW1)
Tyrosine-protein kinase SYK (1XBB)
Mitogen-activated protein kinase 14 (3HEC)
Bcr-Abl protein
Sorafenib (BAX) 4 B-Raf proto-oncogene serine/threonine-protein (1UWH)
Vascular endothelial growth factor (4ASD)
Cyclin-dependent kinase 8 (3RGF)
Mitogen-activated protein kinase 14 (3GCS)
Dihydrotestosterone (DHT) 3 Sex hormone-binding globulin (1D2S)
Estradiol 17-beta-dehydrogenase 1 (3KLM)
Androgen receptor (1I37)
Estradiol (EST) 5 Short chain 3-hydroxyacyl-CoA dehydrogenase (1E6W)
Sex hormone-binding globulin (1LHU)
17-beta-hydroxysteroid-dehydrogenase (1FDS)
Estrogen sulfotransferase (1AQU)
Estrogen receptor beta (2J7X)
Triiodothyronine (T3) 4 Transthyretin (1SN5)
Thyroid receptor alpha (THRA) protein (2H79)
Androgen receptor (2PIV)
Proliferating cell nuclear antigen (3VKX)
Resveratrol (STL) 7 Sulfotransferase family cytosolic 1B (3CKL)
Transthyretin (1DVS)
Myosin-2 heavy chain (3MNQ)
Leukotriene A-4 hydrolase (3FTS)
NRH dehydrogenase [quinone] 2 (1SG0)
Protein (chalcone synthase) (1CGZ)
Methionine adenosyltransferase 2 subunit (2YDX)
Epigallocatechin gallate (EGCG; KDH) 3 Polymerase subunit PA (4AWM)
Transthyretin (3NG5)
Peptidyl-prolyl cis-trans isomerase NIMA-inte (3OOB)
Theophylline (TEP) 3 Chitinase
Apolipoprotein A-I-binding protein
Pyridoxal kinase
Pioglitazone (P1B) 2 Peroxisome proliferator-activated receptor ga
Amine oxidase [flavin-containing] b