Table 2 Multiple targets of selected drugs and natural products in the MTLD
From: Creation of a free, Internet-accessible database: the Multiple Target Ligand Database
Ligand (ligand-ID) | Target number | Targets (PDB-ID) |
|---|---|---|
Sutent (B49) | 4 | Mast/stem cell growth factor (3G0E) |
Phosphorylase b kinase gamma (2Y7J) | ||
Cyclin-dependent kinase 2 (3TI1) | ||
Tyrosine-protein kinase ITK/TSK (3MIY) | ||
Imatinib (STI) | 5 | Homo sapiens v-kit Hardy–Zuckerman (1 T46) |
Ribosyldihydronicotinamide dehydrogenase (3FW1) | ||
Tyrosine-protein kinase SYK (1XBB) | ||
Mitogen-activated protein kinase 14 (3HEC) | ||
Bcr-Abl protein | ||
Sorafenib (BAX) | 4 | B-Raf proto-oncogene serine/threonine-protein (1UWH) |
Vascular endothelial growth factor (4ASD) | ||
Cyclin-dependent kinase 8 (3RGF) | ||
Mitogen-activated protein kinase 14 (3GCS) | ||
Dihydrotestosterone (DHT) | 3 | Sex hormone-binding globulin (1D2S) |
Estradiol 17-beta-dehydrogenase 1 (3KLM) | ||
Androgen receptor (1I37) | ||
Estradiol (EST) | 5 | Short chain 3-hydroxyacyl-CoA dehydrogenase (1E6W) |
Sex hormone-binding globulin (1LHU) | ||
17-beta-hydroxysteroid-dehydrogenase (1FDS) | ||
Estrogen sulfotransferase (1AQU) | ||
Estrogen receptor beta (2J7X) | ||
Triiodothyronine (T3) | 4 | Transthyretin (1SN5) |
Thyroid receptor alpha (THRA) protein (2H79) | ||
Androgen receptor (2PIV) | ||
Proliferating cell nuclear antigen (3VKX) | ||
Resveratrol (STL) | 7 | Sulfotransferase family cytosolic 1B (3CKL) |
Transthyretin (1DVS) | ||
Myosin-2 heavy chain (3MNQ) | ||
Leukotriene A-4 hydrolase (3FTS) | ||
NRH dehydrogenase [quinone] 2 (1SG0) | ||
Protein (chalcone synthase) (1CGZ) | ||
Methionine adenosyltransferase 2 subunit (2YDX) | ||
Epigallocatechin gallate (EGCG; KDH) | 3 | Polymerase subunit PA (4AWM) |
Transthyretin (3NG5) | ||
Peptidyl-prolyl cis-trans isomerase NIMA-inte (3OOB) | ||
Theophylline (TEP) | 3 | Chitinase |
Apolipoprotein A-I-binding protein | ||
Pyridoxal kinase | ||
Pioglitazone (P1B) | 2 | Peroxisome proliferator-activated receptor ga |
Amine oxidase [flavin-containing] b |