An illustrative example of two-way ANOVA (sigma restricted parametrization). A general, but not exclusive trend is to observe higher SRD values for the ranking of diversity picked molecules, which implies that the consensus of the discussed similarity metrics gets weaker as we investigate more diverse compound sets. Influential factors are shown using weighted means. The line plots are shifted on the categorical x axis horizontally for clarity. The vertical bars denote 0.95 confidence intervals.