Why is Tanimoto index an appropriate choice for fingerprint-based similarity calculations?

Table 1 Size classes of molecules and their definitions

Class	Criteria	Total count in the Mcule database	Reference
Fragment	M_W ≤ 250	166.458	[38]
	logP ≤ 3.5
	rotB ≤ 5
Leadlike	250 ≤ M_W ≤ 350	1.234.403	[39]
	logP ≤ 3.5
	rotB ≤ 7
Druglike	150 ≤ M_W ≤ 500	3.745.649	[40]
	logP ≤ 5
	rotB ≤ 7
	PSA < 150
	HBD ≤ 5
	HBA ≤ 10

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