Figure 5

Physicochemical properties of compounds in the database, based on Lipinski’s “rule of five”. a Bar graph of compounds grouped by number of hydrogen bond acceptors; b bar graph of compounds grouped by number of hydrogen bond donors; c scatter plot of the LogP of each compound, plotted against their mass. The red dotted lines indicate the cut-off Lipinski values for each axis (LogP ≤5 and mass ≤500 Da); d tabulated grouping of compounds in the database with their number of violations of Lipinski’s “rule of five”.