Table 4 Shows the types of data we used the drug target interaction having more than 1 and 2 drug interactions and sensitivity (hit rate) at top 10, 25, 50, 100 and 200 predicted targets
From: Optimizing drug–target interaction prediction based on random walk on heterogeneous networks
Data types | Number of targets | Top 10 (%) | Top 25 (%) | Top 50 (%) | Top 100 (%) | Top 200 (%) |
|---|---|---|---|---|---|---|
ChEMBL 1 μM (RWR) | >0 | 0.144 | 0.342 | 0.470 | 0.532 | 0.607 |
ChEMBL 1 μM (Seq) | >0 | 0.164 | 0.315 | 0.394 | 0.420 | 0.430 |
ChEMBL 1 μM (random RWR) | >0 | 0.002 | 0.013 | 0.018 | 0.036 | 0.021 |
ChEMBL 10 μM (RWR) | >0 | 0.11 | 0.247 | 0.324 | 0.386 | 0.409 |
ChEMBL 10 μM (Seq) | >0 | 0.122 | 0.183 | 0.234 | 0.249 | 0.254 |
ChEMBL 10 μM (random RWR) | >0 | 0.014 | 0.023 | 0.035 | 0.048 | 0.079 |
ChEMBL 1 μM (RWR) | >1 | 0.274 | 0.477 | 0.550 | 0.580 | 0.614 |
ChEMBL 1 μM (seq) | >1 | 0.189 | 0.350 | 0.428 | 0.472 | 0.513 |
ChEMBL 1 μM (random RWR) | >1 | 0.007 | 0.023 | 0.038 | 0.076 | 0.091 |
ChEMBL 10 μM (RWR) | >1 | 0.220 | 0.277 | 0.348 | 0.417 | 0.446 |
ChEMBL 10 μM (seq) | >1 | 0.13 | 0.212 | 0.276 | 0.296 | 0.302 |
ChEMBL 10 μM (Random RWR) | >1 | 0.014 | 0.023 | 0.035 | 0.048 | 0.079 |
ChEMBL 1 μM (RWR) | >2 | 0.271 | 0.518 | 0.598 | 0.634 | 0.677 |
ChEMBL 1 μM (seq) | >2 | 0.19 | 0.393 | 0.53 | 0.56 | 0.598 |
ChEMBL 1 μM | >2 | 0.006 | 0.018 | 0.034 | 0.055 | 0.08 |
ChEMBL 10 μM (RWR) | >2 | 0.233 | 0.297 | 0.353 | 0.4299 | 0.472 |
ChEMBL 10 μM (seq) | >2 | 0.13 | 0.22 | 0.295 | 0.316 | 0.324 |
ChEMBL 10 μM (Random RWR) | >2 | 0.012 | 0.028 | 0.040 | 0.057 | 0.093 |