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Table 4 Shows the types of data we used the drug target interaction having more than 1 and 2 drug interactions and sensitivity (hit rate) at top 10, 25, 50, 100 and 200 predicted targets

From: Optimizing drug–target interaction prediction based on random walk on heterogeneous networks

Data types Number of targets Top 10 (%) Top 25 (%) Top 50 (%) Top 100 (%) Top 200 (%)
ChEMBL 1 μM (RWR) >0 0.144 0.342 0.470 0.532 0.607
ChEMBL 1 μM (Seq) >0 0.164 0.315 0.394 0.420 0.430
ChEMBL 1 μM (random RWR) >0 0.002 0.013 0.018 0.036 0.021
ChEMBL 10 μM (RWR) >0 0.11 0.247 0.324 0.386 0.409
ChEMBL 10 μM (Seq) >0 0.122 0.183 0.234 0.249 0.254
ChEMBL 10 μM (random RWR) >0 0.014 0.023 0.035 0.048 0.079
ChEMBL 1 μM (RWR) >1 0.274 0.477 0.550 0.580 0.614
ChEMBL 1 μM (seq) >1 0.189 0.350 0.428 0.472 0.513
ChEMBL 1 μM (random RWR) >1 0.007 0.023 0.038 0.076 0.091
ChEMBL 10 μM (RWR) >1 0.220 0.277 0.348 0.417 0.446
ChEMBL 10 μM (seq) >1 0.13 0.212 0.276 0.296 0.302
ChEMBL 10 μM (Random RWR) >1 0.014 0.023 0.035 0.048 0.079
ChEMBL 1 μM (RWR) >2 0.271 0.518 0.598 0.634 0.677
ChEMBL 1 μM (seq) >2 0.19 0.393 0.53 0.56 0.598
ChEMBL 1 μM >2 0.006 0.018 0.034 0.055 0.08
ChEMBL 10 μM (RWR) >2 0.233 0.297 0.353 0.4299 0.472
ChEMBL 10 μM (seq) >2 0.13 0.22 0.295 0.316 0.324
ChEMBL 10 μM (Random RWR) >2 0.012 0.028 0.040 0.057 0.093