Table 2 Comparison between methods over six different datasets based on LOOCV for each drug, assuming no DTIs are known for each drug. This is equivalent to estimating capacity to predict DTIs for new drugs without known targets
From: DASPfind: new efficient method to predict drug–target interactions
Data | Method | ‘Top 1’ (%) |
|---|---|---|
Enzyme | NRWRH | 18.65 |
HGBI | 43.6 | |
DASPfind | 49.66 | |
Ion channels | NRWRH | 33.33 |
HGBI | 35.71 | |
DASPfind | 44.28 | |
GPCR | NRWRH | 25.56 |
HGBI | 42.15 | |
DASPfind | 51.12 | |
Nuclear receptors | NRWRH | 31.48 |
HGBI | 46.30 | |
DASPfind | 51.85 | |
HGBI_Dataset | NRWRH | 5.04 |
HGBI | 11.36 | |
DASPfind | 11.49 | |
DrugBank_Approved | NRWRH | 7.9 |
HGBI | 24.49 | |
DASPfind | 45.69 |