Table 3 Top five predicted interactions from DrugBank approved drugs database
From: DRABAL: novel method to mine large high-throughput screening assays using Bayesian active learning
Rank | AID 1458 Target: Survival of motor neuron 2 (DRABAL score) | AID 485297 Target: Ras-related protein Rab-9A (DRABAL score) | AID 485313 Target: Niemann-Pick C1 protein precursor (DRABAL score) | AID 588342 Target: Luciferase transcriptional reporter (DRABAL score) | AID 686978 Target: Tyrosyl-DNA phosphodiesterase 1 (DRABAL score) |
|---|---|---|---|---|---|
1 | Amlexanox DB01025 (0.48) | Nitazoxanide DB00507 (0.67) | Thiabendazole DB00730 (0.33) | Phenazopyridine DB01438 (0.68) | Vinblastine DB00570 (0.99) |
2 | Mycophenolate mofetil DB00688 (0.3) | Thiabendazole DB00730 (0.61) | Omeprazole DB00338 (0.21) | Mitoxantrone DB01204 (0.53) | Plicamycin DB06810 (0.99) |
3 | Rabeprazole DB01129 (0.2) | Omeprazole DB00338 (0.23) | Phenazopyridine DB01438 (0.21) | Phenindione DB00498 (0.49) | Bromocriptine DB01200 (0.98) |
4 | Pramipexole DB00413 (0.14) | Nabumetone DB00461 (0.19) | Mebendazole DB00643 (0.12) | Olsalazine DB01250 (0.47) | Ketoconazole DB01026 (0.98) |
5 | Idoxuridine DB00249 (0.13) | Mycophenolic acid DB01024 (0.18) | Olsalazine DB01250 (0.12) | Amsacrine DB00276 (0.44) | Teniposide DB00444 (0.97) |