Fig. 4

Example of a network examining relationship between two drugs (Dq and De). Dq: a query drug, for which potential DDIs are predicted with a drug under examination, De; T1: a target protein for De (source DrugBank); P1, P2: proteins that have physical interactions with T1 (source BioGRID); E1, E2: enzymes of De (source DrugBank); Tr1, Tr2: transporters of De (source DrugBank); D1 through D12: drugs associating with the proteins including T1, P1, P2, E1, E2, Tr1, and Tr2 in the network; protein–protein interaction (source BioGRID): purple line; pharmacogenetic association (source PharmGKB): blue line; PK-related interaction (source DrugBank): brown line; drug-target interaction (source DrugBank): green line. S_d, S_e1, S_e2, S_e3, S_eg1, S_tr1, S_tr2, S_trg1, S_ta1, S_ta2, S_ta3, S_tag1, S_tag2: similarity scores between Dq and drugs in De’s network (D1 through D12)