Fig. 10

Candidate chemotypes for orthogonal EGFR covalent inhibition, prioritized based on the binding data of Abbott [46]. Values for individual inhibitors are plotted according to ALK and MET binding strengths, with chemotypes indicated by symbol (and defined for the tightest binders) and EGFR binding strengths indicated by color (red = 1 nM, violet = 10 nM, blue = 100 nM). The complete structure of the inhibitor for which the data point is plotted, is disclosed in the analysis [46], and the corresponding substituents are depicted for this chemotype in the figure at lower saturation