Fig. 1From: Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseasesThe computational strategy for rational design of A1R/A2AR–PDE10A multi-target ligands started with a focused chemical space consisting of known actives of A1R, A2AR and PDE10A, and formed new synthetically feasible compounds which were subjected to target prediction and docking for synthesis and pharmacological evaluationBack to article page