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Table 1 The details of the Loose and Rigorous filtering options

From: BoBER: web interface to the base of bioisosterically exchangeable replacements

  Loose filtering Rigorous filtering
Bioisosteric fragment pair is from the same SCOP family Both (inter- and intra-family) Intra-family
Interchangeability of similar join atom types Irrelevanta Non-interchangeable join atom types
Consideration of join atoms Use structures with common core as queries (ignore join atoms) Use specific structure as query (consider join atoms)
  1. aJoin atoms are ignored when the option Use structures with common core as queries is enabled