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Table 6 Targets selected by the target pharmacophore screening with fit value > 0.9

From: Predictive classification models and targets identification for betulin derivatives as Leishmania donovani inhibitors

ID Uniprot ID Gene name Title Family
3ac3 P06239 LCK_HUMAN Tyrosine-protein kinase Lck Protein kinase
3ad4 P06239 LCK_HUMAN Tyrosine-protein kinase Lck Protein kinase
3mzs P00189 CP11A_BOVIN Cholesterol side-chain cleavage enzyme, mitochondrial Cytochrome P450
3my0 P37023 ACVL1_HUMAN Serine/threonine-protein kinase receptor R3 Protein kinase
1lox P12530 LOX15_RABIT Arachidonate 15-lipoxygenase Lipoxygenase
1qyx P14061 DHB1_HUMAN Estradiol 17-beta-dehydrogenase 1 Short chain dehydrogenases/reductases (SDR)
2bik P11309 PIM1_HUMAN Serine/threonine-protein kinase pim-1 Protein kinase
2br1 O14757 CHK1_HUMAN Serine/threonine-protein kinase Chk1 Protein kinase
2chw P48736 PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PI3/PI4 kinase
2chz P48736 PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PI3/PI4 kinase
2p0m P12530 LOX15_RABIT Arachidonate 15-lipoxygenase Lipoxygenase
2wxq Q3UDT3 Q3UDT3_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform PI3/PI4 kinase
3ddu P48147 PPCE_HUMAN Prolyl endopeptidase Peptidase S9A
3h3c Q14289 FAK2_HUMAN Protein-tyrosine kinase 2-beta Protein kinase
3hrb Q16539 MK14_HUMAN Mitogen-activated protein kinase 14 Protein kinase
3le6 P24941 CDK2_HUMAN Cyclin-dependent kinase 2 Protein kinase
3mqe Q05769 PGH2_MOUSE Prostaglandin G/H synthase 2 Prostaglandin G/H synthase
3p2v P15121 ALDR_HUMAN Aldose reductase Aldo/keto reductase
3r7r P48736 PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PI3/PI4 kinase
3rgz O22476 BRI1_ARATH Protein brassinosteroid insensitive 1 Protein kinase
3s3g P15121 ALDR_HUMAN Aldose reductase Aldo/keto reductase
3tfq P28845 DHI1_HUMAN Corticosteroid 11-beta-dehydrogenase isozyme 1 Short chain dehydrogenases/reductases (SDR)
3ugr P42330 AK1C3_HUMAN Aldo-keto reductase family 1 member C3 Aldo/keto reductase
3zrl P49841 GSK3B_HUMAN Glycogen synthase kinase-3 beta Protein kinase
4a79 P27338 AOFB_HUMAN Amine oxidase [flavin-containing] B Flavin monoamine oxidase
2hpy P02699 OPSD_BOVIN Rhodopsin G-protein coupled receptor 1
3gql P11362 FGFR1_HUMAN Fibroblast growth factor receptor 1 Protein kinase
2ab2 P08235 MCR_HUMAN Mineralocorticoid receptor Nuclear hormone receptor
3lmp P37231 PPARG_HUMAN Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor
1pzo P62593 BLAT_ECOLX Beta-lactamase TEM Class-A beta-lactamase
1zhx P35844 KES1_YEAST Oxysterol-binding protein homolog 4 Oxysterol-binding protein
1zhz P35844 KES1_YEAST Oxysterol-binding protein homolog 4 Oxysterol-binding protein
2oxd P28523 CSK2A_MAIZE Casein kinase II subunit alpha Protein kinase
2x00 Q8WSF8 Q8WSF8_APLCA Soluble acetylcholine receptor Neurotransmitter-gated ion-channel
3hgy Q7B8P6 Q7B8P6_CAMJU cmeR Transcriptional regulator
3ov4 P00947 SDIS_COMTE Steroid delta-isomerase Steroid delta-5-4-isomerase
3s92 Q15059 BRD3_HUMAN Bromodomain-containing protein 3 Bromodomain and extraterminal domain
3smo P31947 1433S_HUMAN 14-3-3 protein sigma 14-3-3 protein
4a01 O22124 O22124_VIGRA Pyrophosphate-energized vacuolar membrane proton pump H(+)-translocating pyrophosphatase (TC 3.A.10)
4a86 P15494 BEV1A_BETPN Major pollen allergen Bet v 1-A Bet v I type allergen
4a8v P43183 BEV1J_BETPN Major pollen allergen Bet v 1-J Bet v I type allergen
2iws P02829 HSP82_YEAST ATP-dependent molecular chaperone HSP82 Heat shock protein Hsp90
3b27 P07900 HS90A_HUMAN Heat shock protein HSP 90-alpha Heat shock protein Hsp90
2xa4 O60674 JAK2_HUMAN Tyrosine-protein kinase JAK2 Protein kinase
4a9n P25440 BRD2_HUMAN Bromodomain-containing protein 2 Bromodomain and extraterminal domain
4alh P25440 BRD2_HUMAN Bromodomain-containing protein 2 Bromodomain and extraterminal domain
3svg O60885 BRD4_HUMAN Bromodomain-containing protein 4 Bromodomain and extraterminal domain