Table 1 Standardization rejection rates

Number of substances

102,428,688

53,097

2,188,004

104,669,789

Verify element

107

14

20

141

Verify hydrogens

–

–

–

–

Verify functional groups

–

–

–

–

Verify valence

242,615

836

122,034

365,485

Standardize annotations

–

–

–

Standardize valence bond

8245

165

1833

10,243

Standardize aromaticity

–

–

–

Standardize stereochemistry

–

–

–

Standardize explicit hydrogens

458

–

28

486

Rejected substances

251,425

1015

123,915

376,355

Rejection rate

0.25%

1.91%

5.66%

0.36%

Successfully standardized substances

102,177,263

52,082

2,064,089

104,293,434

Success rate

99.75%

98.09%

94.34%

99.64%