Fig. 5
From: Probing the chemical–biological relationship space with the Drug Target Explorer
Exploration of similar molecules in biological datasets. a A search for ABT-737 identifies similarly-acting BCL family inhibitors in the CCLE dataset, including ABT-199, navitoclax, and combinations of navitoclax with other drugs. b A search for 2′-deoxycytidine identifies the most structurally similar molecule in the CCLE dataset (cytarabine HCl) and identifies several molecules with highly and significantly correlated drug responses, including clofarabine, gemcitabine, and decitabine