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Table 6 Enrichment factor values (EF1%) by DLIGAND2, AutoDock Vina, ΔvinaRF20, DLIGAND, X-ScoreHM, ID-Score on eight protein categories

From: DLIGAND2: an improved knowledge-based energy function for protein–ligand interactions using the distance-scaled, finite, ideal-gas reference state

  DLIGAND2 Vina ΔvinaRF20 DLIGAND X-ScoreHM ID-Score
Cytochrome P450 6.48 1.93 3.77 5.10 3.59 0.56
GPCR 8.46 2.48 4.17 3.79 1.56 1.49
Ion channel 0.84 4.47 3.48 0.51 0.00 0.83
Kinase 10.01 6.10 7.50 4.41 5.93 1.04
Miscellaneous 6.89 5.65 7.82 6.63 4.46 5.36
Nuclear receptors 5.42 9.14 9.57 4.57 4.01 1.69
Other enzymes 3.23 3.88 4.76 2.52 2.64 1.21
Protease 10.16 4.63 6.99 8.65 5.58 2.57
Average 6.43 4.79 6.01 4.52 3.47 1.84
  1. Italic fonts highlight the highest value in each category