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Fig. 7 | Journal of Cheminformatics

Fig. 7

From: Identifying new topoisomerase II poison scaffolds by combining publicly available toxicity data and 2D/3D-based virtual screening

Fig. 7

Effect of the test compounds on Top2-mediated decatenation of kinetoplast DNA (KDNA). Dose-dependent poisoning was calculated from DNA samples separated by gel electrophoresis. Symbols represent experimental data, continuous curves are fitted lines. Red: mitoxantrone, black: NSC637992, blue: NSC317921, green: NSC691240, purple: NSC660839. Filled and open circles represent scaffold hopping and decoy molecules, respectively. A representative gel photo is shown in Additional file 1: Fig S5

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Journal of Cheminformatics

ISSN: 1758-2946

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