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Table 2 Calculated Top2 poisoning IC50 values of test compounds

From: Identifying new topoisomerase II poison scaffolds by combining publicly available toxicity data and 2D/3D-based virtual screening

NSC

IC50 (μM)

95% CI (μM)

Mitoxantrone

3.3

2.6–4.1

637992

3.3

2.5–4.6

317921

7.5

5.9–9.6

691240

12.1

9.0–16.3

660839

\(>100\)

NA

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Journal of Cheminformatics

ISSN: 1758-2946

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