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Table 1 Several drug repurposing tools compared with ACID

From: ACID: a free tool for drug repurposing using consensus inverse docking strategy

NameMethodSample setaPrediction performanceDate of last updateRefs.
Similarity comparison based approaches
 ChemMapper3D similarity approach216/70690.7Dec 2016[25]
 ChemProt 3.02D similarity approach248/17000.827Jan 2015[26]
 HitPick1NN similarity search approach3430/31169260.61dMay 2013[27]
 SwissTarget-predictionCombination of 2D and 3D similarity approach346/17300.87Apr 2014[28]
Docking algorithm based approaches
 idTargetDivide and conquer based docking approach1/3/1161, 1/4/11610.89, 0.91Aug 2015[13]
 INVDOCKInverse docking approach2/23/270050%eMay 2001[10]
 TarFisDockReverse docking approach1/10/37, ··· 1/12/37133%/33%/58%, 30%/20%/50%Aug 2014[11]
 ACIDConsensus inverse docking approach51/133/8310.8447%/57%/68%Dec 2018 
  1. aThe sample set is number of positive/negative interactions for the similarity comparison based approaches, and is number of drugs/known targets/decoys for docking algorithm based approaches
  2. bThe AUC (Area Under Curve) is used to represent the prediction performance in the references cited, the closer the AUC value is to 1, the better the prediction performance is
  3. cThe TOP is the percentage of the top 2%/5%/10% candidates identified by the tools (except INVDOCK) to represent the prediction performance in the references cited, the higher the value of the TOP, the better the performance
  4. dFor HitPick, a sensitivity of 60.94%, a specificity of 99.99% and a precision of 92.11% is indicated in the references cited, normally, we can infer that the AUC of this tool is smaller than 0.61
  5. eFor INVDOCK, the TOP is the percentage of candidates identified by the tool, but the top percentage isn’t indicated in the references cited, the maximum value 50 is indicated