Predicting liver cytosol stability of small molecules

Table 1 Reproducibility across different experiments

Compound	# Repeats^a	t_1/2 (mean ± SD)/category (Mouse cytosol)^b	t_1/2 (mean ± SD)/category (Human cytosol)^b
Buspirone	17	>120 min/High	>120 min/High
Antipyrine	17	>120 min/High	>120 min/High
Famciclovir	17	9.5 ± 3.2 min/Low	10.0 ± 3.1 min/Low
Carbazeran	17	>120 min/High	3.5 ± 1.8 min/Low

^at_1/2 values of the control compounds across 17 plates were measured by UHPLC/HRMS. t_1/2 categories: < 10 min: low; > 30 min: high
^bNo SD values provided if all replicate t_1/2 values exceeded 120 min

ISSN: 1758-2946