Skip to main content

Table 1 Reproducibility across different experiments

From: Predicting liver cytosol stability of small molecules

Compound# Repeatsat1/2 (mean ± SD)/category
(Mouse cytosol)b
t1/2 (mean ± SD)/category
(Human cytosol)b
Buspirone17>120 min/High>120 min/High
Antipyrine17>120 min/High>120 min/High
Famciclovir179.5 ± 3.2 min/Low10.0 ± 3.1 min/Low
Carbazeran17>120 min/High3.5 ± 1.8 min/Low
  1. at1/2 values of the control compounds across 17 plates were measured by UHPLC/HRMS. t1/2 categories: < 10 min: low; > 30 min: high
  2. bNo SD values provided if all replicate t1/2 values exceeded 120 min