Table 1 Aromatic–aromatic cluster complexes properties in protein–drug, protein–protein and intraprotein
From: Aromatic clusters in protein–protein and protein–drug complexes
Property | Protein–drug | Protein–protein | Intraprotein |
|---|---|---|---|
≥ 1 Aromatic cluster complexes | 5908 | 3048 | 9760 |
Number of clusters | 7236 | 7717 | 73,312 |
Average number of clusters | 1.22 | 2.53 | 7.51 |
Number of interactions | 23,303 | 15,309 | 277,797 |
Average number of Interactions per cluster | 3.22 | 1.98 | 3.78 |
Proportion of interacting aromatic residues (%PHE, %TYR, %TRP, %HIS) | 34.8%, 26.5%, 21.7%, 16.8% | 36.7%, 25.3%, 20.7%, 17.1% | 35.2%, 24.5%, 25.4%, 14.6% |
Proportion of secondary structures for interacting residues (%Loop, %Sheet, %Helix) | 43.4%, 23.6%, 32.9% | 34.3%, 22.4%, 43.2% | 32.5%, 27.3%, 40.1% |
Average % exposure of aromatic residues | 17.29 | 34.63 | 9.18 |