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Table 1 Aromatic–aromatic cluster complexes properties in protein–drug, protein–protein and intraprotein

From: Aromatic clusters in protein–protein and protein–drug complexes

PropertyProtein–drugProtein–proteinIntraprotein
≥ 1 Aromatic cluster complexes590830489760
Number of clusters7236771773,312
Average number of clusters1.222.537.51
Number of interactions23,30315,309277,797
Average number of Interactions per cluster3.221.983.78
Proportion of interacting aromatic residues (%PHE, %TYR, %TRP, %HIS)34.8%, 26.5%, 21.7%, 16.8%36.7%, 25.3%, 20.7%, 17.1%35.2%, 24.5%, 25.4%, 14.6%
Proportion of secondary structures for interacting residues (%Loop, %Sheet, %Helix)43.4%, 23.6%, 32.9%34.3%, 22.4%, 43.2%32.5%, 27.3%, 40.1%
Average  % exposure of aromatic residues17.2934.639.18