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Table 2 Inhibitory activity of the three synthesized molecules

From: Chemical space exploration based on recurrent neural networks: applications in discovering kinase inhibitors

Compound

Inhibition for CDK4 at 10 μM (%)

Inhibition for CDK4 at 100 μM (%)

Inhibition for Pim1 at 10 μM (%)

MJ-4

10.96 ± 2.57

72.77 ± 1.24

< 10

MJ-115

35.82 ± 3.75

90.74 ± 1.28

10.38 ± 6.39

MJ-1055

21.06 ± 1.45

81.5 ± 2.2

99.64 ± 0.08

  1. The tests were performed with at least two replicates
  2. Staurosporine was tested as the positive control. Its IC50 values for Pim1 and CDK4 are 46 nM and 30 nM, respectively
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Journal of Cheminformatics

ISSN: 1758-2946

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