Drug repositioning strategy | Data resource | Description (as of January 2020) |
---|---|---|
Genome | ArrayExpress Ê61] | A repository of high-throughput functional genomics experiments data |
A combination of gene expression, chromosomal copy number, and massively parallel sequencing data from human cancer cell lines | ||
Database for Annotation, Visualization and Integrated Discovery (DAVID) [63] | A comprehensive set of functional annotation tools | |
A platform for comparing drug and disease gene expression profiles retrieved from publicly available microarray data resources | ||
A tool to explore gene expression data across species and different biological conditions | ||
A repository of gene expression profiles | ||
A tool for interpreting gene expression data | ||
A repository of gene signatures data reported in the literature | ||
A repository of functional genomics | ||
A repository of genomic data for many cancer types | ||
A repository of genome sequencing and high-throughput functional genomics experiments molecular datasets | ||
Library of Integrated Network-based Cellular Signatures (LINCS) [72] | A catalog of gene expression data and how human cells respond to different genetic and environmental conditions | |
A repository of annotated gene sets and expression profiles | ||
A repository of genomic data for more than 30 cancer types | ||
A collection of genome-wide transcriptional expression data | ||
A repository of protein sequence and functional information | ||
Phenome | A repository of publicly and privately funded clinical studies from around the world | |
A repository of adverse drug reactions related to drugs. Information includes drug side effects and side effects classifications | ||
Chemical structure | A repository of drug structural information, such as 3D structures, and abstracted biological activities, extracted from the scientific literature | |
A repository of chemical structure information | ||
ChemSpider [81] | A repository of chemical structure information | |
A repository of drug-related information, such as chemical structure for drugs | ||
A repository of drug-related information such as chemical structure and biological activities | ||
A repository of chemical substances and their biological activities | ||
A repository of 3D shape of proteins and nucleic acids information | ||
A repository of 2D and 3D drug chemical structure information, including approved and illegal drugs | ||
A collection of chemical structure information related to approved and investigational drugs | ||
Therapeutic Target Database (TTD) [87] | A repository of drug-related information such as 3D structure, therapeutic class, and clinical development status | |
Phenome/genome | A repository of approved and failed drug-disease associations | |
A repository of human genes and genetic phenotype information | ||
The Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB) [90] | A repository of drug-related information such as drug labels, drug-gene associations, and genotype-phenotype relationships | |
Phenome/chemical structure | A repository of FDA approved drugs and related information |