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Table 3 Correlation coefficients (CCs) between log2IR and six performance metrics plus the average of nine metrics in Table 2 for all four classification algorithms

From: Structure–activity relationship-based chemical classification of highly imbalanced Tox21 datasets

Metrics Algorithms
RF RUS SMO SMN
F1 score − 0.7217 − 0.7394 − 0.6941 − 0.9817
MCC − 0.5778 − 0.6180 − 0.6419 − 0.9761
BA − 0.6539 − 0.6274 − 0.6227 − 0.9461
AUPRC − 0.7034 − 0.7148 − 0.8418 − 0.9628
AUROC − 0.277 − 0.1589 − 0.3713 − 0.7417
SSG 0.7158 0.7072 0.7006 0.9195
Average − 0.6536 − 0.8421 − 0.7725 − 0.9822
  1. Insignificant CCs are highlighted in bold and are those whose absolute values are smaller than 0.5760, the critical value at α = 0.05 significance level for the degree of freedom df = 10 (i.e., n−2, where n = 12 assays)