Table 1 Number of compounds available from different data sources (PDB, ChEMBL, IUPHAR, PubChem) for the five top-ranked protein targets retrieved from both the UniProt pre-release web page and the Open Targets Platform
Target shortcut | Target source | PDB | ChEMBL | IUPHAR | PubChem | # Unique active compounds |
|---|---|---|---|---|---|---|
PPIA_HUMAN | UniProt pre-release | 57 | 2 | 1 | 3123 | 3183 |
CATL1_HUMAN | UniProt pre-release | 25 | 38 | 4 | 946 | 1003 |
ITAL_HUMAN | UniProt pre-release | 13 | 94 | 2 | 550 | 564 |
FURIN_HUMAN | UniProt pre-release | 4 | 10 | 1 | 448 | 463 |
R1AB_CVHSA | UniProt pre-release | 37 | 187 | 0 | 47 | 227 |
GABRG2_HUMAN | Open Targets Platform | 152 | 0 | 677 | 2 | 831 |
MMP13_HUMAN | Open Targets Platform | 319 | 3 | 80 | 28 | 430 |
GABRB1_HUMAN | Open Targets Platform | 121 | 0 | 166 | 0 | 287 |
DPP4_HUMAN | Open Targets Platform | 140 | 2 | 29 | 14 | 185 |
GABRA1_HUMAN | Open Targets Platform | 3 | 4 | 172 | 2 | 181 |