Development of Natural Compound Molecular Fingerprint (NC-MFP) with the Dictionary of Natural Products (DNP) for natural product-based drug development

Table 2 The classes of the Dictionary of Natural Products (DNP) and scaffold levels are listed

No	Class^a	Class designation	No. of representative compounds^b	No. of scaffolds (Lv0)^c	No. of scaffolds (Lv1)^d	No. of scaffolds (Lv2)^e	No. of scaffolds (Lv3)^f
1	Aliphatic natural products	ANP	31	16	10	4	3
2	Alkaloids	Alk	303	107	177	218	190
3	Aminoacids and peptides	Ape	13	9	9	7	5
4	Benzofuranoids	Bfu	11	5	6	6	3
5	Benzopyranoids	Bpy	15	7	8	4	4
6	Carbohydrates	Car	30	10	13	14	10
7	Flavonoids	Fla	19	8	8	10	2
8	Lignans	Lig	20	9	10	9	1
9	Oxygen heterocycles	Oxy	12	8	7	3	1
10	Polycyclic aromatic natural products	PANP	13	6	8	8	3
11	Polyketides	Pke	12	10	9	11	8
12	Polypyrroles	Ppy	6	6	6	6	6
13	Simple aromatic natural products	SANP	18	9	10	7	0
14	Steroids	Ste	17	5	5	5	6
15	Tannins	Tan	21	8	8	9	6
16	Terpenoids	Ter	141	34	33	28	14
Total			682	257	327	349	262

DNP are listed with its’ designated name. The number of representative compounds of each class are listed. The number of scaffolds at level 0, 1, 2, and 3 are summarized
^aFrom Dictionary of Natural Product database (DNP), 16 classes were introduced
^bThe number of representative natural compounds in each group of the DNP (“No. of NC representative group in DNP”)
^cThe number of scaffold level 0. (“No. of scaffolds (Lv0)”)
^dThe number of scaffold level 1. (“No. of scaffolds (Lv1)”)
^eThe number of scaffold level 2. (“No. of scaffolds (Lv2)”)
^fThe number of scaffold level 3. (“No. of scaffolds (Lv3)”)

ISSN: 1758-2946