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Table 2 The classes of the Dictionary of Natural Products (DNP) and scaffold levels are listed

From: Development of Natural Compound Molecular Fingerprint (NC-MFP) with the Dictionary of Natural Products (DNP) for natural product-based drug development

NoClassaClass designationNo. of representative compoundsbNo. of scaffolds (Lv0)cNo. of scaffolds (Lv1)dNo. of scaffolds (Lv2)eNo. of scaffolds (Lv3)f
1Aliphatic natural productsANP31161043
2AlkaloidsAlk303107177218190
3Aminoacids and peptidesApe139975
4BenzofuranoidsBfu115663
5BenzopyranoidsBpy157844
6CarbohydratesCar3010131410
7FlavonoidsFla1988102
8LignansLig2091091
9Oxygen heterocyclesOxy128731
10Polycyclic aromatic natural productsPANP136883
11PolyketidesPke12109118
12PolypyrrolesPpy66666
13Simple aromatic natural productsSANP1891070
14SteroidsSte175556
15TanninsTan218896
16TerpenoidsTer14134332814
Total682257327349262
  1. DNP are listed with its’ designated name. The number of representative compounds of each class are listed. The number of scaffolds at level 0, 1, 2, and 3 are summarized
  2. aFrom Dictionary of Natural Product database (DNP), 16 classes were introduced
  3. bThe number of representative natural compounds in each group of the DNP (“No. of NC representative group in DNP”)
  4. cThe number of scaffold level 0. (“No. of scaffolds (Lv0)”)
  5. dThe number of scaffold level 1. (“No. of scaffolds (Lv1)”)
  6. eThe number of scaffold level 2. (“No. of scaffolds (Lv2)”)
  7. fThe number of scaffold level 3. (“No. of scaffolds (Lv3)”)