Flame: an open source framework for model development, hosting, and usage in production environments

Table 3 Overview of the main modeling methods and tools implemented natively in Flame

Modeling task	Method	Source
Structure normalization	Standardiser	[34]
Structure normalization	ChEMBL pipeline	[35, 36]
Molecular descriptors calculation	RDKit properties	[37]
	RDKit md	[37]
	RDKit Morgan fingerprints	[37]
Scaling	Raw	–
Scaling	Autoscaling	[9]
Machine learning	RF	[9, 38]
	SVM	[9, 39]
	PLS	[9, 40]
	XGBOOST	[41]
	Conformal regression	[42, 43]

ISSN: 1758-2946