Table 1 Activity thresholds for 26,092 commercial compounds tested at 10 μM concentration against HDAC7, classified on the basis of enzyme activity percent of inhibition
From: “Molecular Anatomy”: a new multi-dimensional hierarchical scaffold analysis tool
Activity class | N. of compounds | % of inhibition |
|---|---|---|
Inactive | 23,750 | < 19 |
Weak | 2141 | 19–33 |
Moderate | 144 | 33–50 |
Strong | 37 | 50–80 |
Very strong | 20 | > 80 |