Fig. 3

Comparison of XYPI and anti-inflammatory drugs in terms of inflammatory and immune pathways. A “drug-target-pathway” heterogeneous network of XYPI and NSAIDs in terms of inflammatory response. The green square was sharing pathway of XYPI and NSAIDs, and the circle was target of XYPI and NSAIDs. Blue circle was unique target of NSAIDs, pink circle for unique target of XYPI, and orange circle for common target of XYPI and NSAIDs. B “drug-target-pathway” heterogeneous network of XYPI and GCs in terms of immune response. The green square was sharing pathway of XYPI and GCs, and the circle was target of XYPI and GCs. Blue circle was unique target of GCs, pink circle for unique target of XYPI, and orange circle for common target of XYPI and GCs. C Expression of sharing pathway after Ketoprofen and Prednisolone treatment based on signature data from LINCS. The upregulated gene ratio was marked for each term. D Significantly differential expressing pathway after Ketoprofen and Prednisolone treatment. Upregulated genes or biological processes by Ketoprofen are marked with yellow, and downregulated ones are marked with blue. For prednisolone, upregulated genes or biological processes are marked with red, and downregulated ones are marked with green