Fig. 4

Transcriptome of XYPI pretreatment in an LPS-activated macrophage cell model. A Comparison of the anti-inflammatory effects of XYPI with those of ketoprofen and prednisolone. The effect of the three agents on expression of the inflammatory factor IL-6 induced by LPS in the supernatant of RAW264.7 cells after 24 h of pre-administration. * indicates the administration group vs the model group p <  = 0.05, ** p <  = 0.01. # indicates the model group vs the blank control group p <  = 0.05, ##p <  = 0.01. B–D Volcano plot (B), PCA (C) and hierarchical clustering (D) of the transcriptome of the control group, model group (LPS-induced macrophage model), and drug group (pretreatment with high-dose XYPI, high-dose ketoprofen and high-dose prednisolone)