Fig. 1
From: Using informative features in machine learning based method for COVID-19 drug repurposing
Overall workflow. Our method integrates a drug–target network with a Human-virus network in the human PPI network. A. Human and coronavirus host proteins were collected from different datasets to generate a COVID-19 related biological network. B. Algorithm 1 (Alg 1) and 2 (Alg 2) detect the essential proteins in the COVID-19 related biological network. Three Informative features introduced. The Machine Learning method used these features and find three significant clusters. C. The resulted clusters evaluated with different measures. These measures are based on drug targets in these clusters. Finally, some candidate drugs recommended