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Table 3 BR prediction performance on the COACH test dataset

From: Sequence-based prediction of protein binding regions and drug–target interactions

Name

COACH (unseen protein–ligand complexes)

COACH (unseen proteins)

Top-n success rate (%)

Top-(n + 2) success rate (%)

Top-n success rate (%)

Top-(n + 2) success rate (%)

Fpocket

59.2

63.5

55.2

59.0

SiteHound

54.8

74.1

52.2

69.6

MetaPocket 2.0

68.3

80.9

64.1

76.3

DeepSite

61.8

67.8

57.5

64.9

P2Rank

74.7

82.0

73.1

79.9

HoTS (proposed)

66.3 ± 0.9

85.26 ± 0.8

59.9 ± 1.3

81.4 ± 0.9